Daxxify®
Smooth your crow’s feet, forehead creases, and frown lines for an entire year with as few as two treatments.
Do you love the results of Botox® or Dysport® but wish the results lasted longer?
Daxxify® is the only long-lasting frown line treatment powered by a peptide that lasts six to nine months. Instead of visiting our office four times a year, now you can maintain your results with twice-yearly appointments.
Save time, look your best.
A longer-lasting injectable
What is Daxxify®?
Like Botox and Dysport, the active ingredient in Daxxify® is botulinum toxin. However, Daxxify® uses a novel peptide as stabilizer.
How is Daxxify® different from other injectable treatments?
All injectable frown line treatments use a special ingredient to stabilize botulinum toxin A, the protein that helps smooth lines and wrinkles. Botox uses human serum albumin (HSA), a blood product, and Dysport uses HSA and cow’s milk protein as a protectant.
Daxxify® is the only formulation that uses a novel peptide as a stabilizer and does not contain human or animal byproducts.
Is Daxxify® well-studied?
Daxxify® is safe. It was part of the largest-ever clinical study for frown line treatment and included more than 2,800 people across different ages and skin types. In this study there were no serious treatment side effects and 96% of the people treated with Daxxify® were satisfied with their results.
The active ingredient in Daxxify® is the same that’s been used in frown line and wrinkle treatments for more than 20 years.
Why Choose Daxxify®
- Fewer treatments, same results
- Long-lasting Botox alternative
- Rapid results, quick recovery
- FDA-approved
What to Expect During Treatment
The procedure is the same as you might have experienced with other frown line injectables. First, you’ll start with a consultation. La Jolla plastic surgeon Dr. Gallus or a medical injector will ask you about your goals, as well as any allergies or medications. The Daxxify® treatment only takes about 20 minutes. Dr. Gallus uses a small needle to inject Daxxify®, and then you can go about your day, returning to work or home.
Will the injections hurt?
Pain from the injection is minimal. Aside from an occasional small amount of bruising, you can expect to immediately return to daily activities or work.
Rest assured that most patients report the discomfort from neurotoxin injections like Botox and Daxxify as being very minimal. Your comfort is our top priority at Restore SD Plastic Surgery, so we provide your treatment in a calming environment and provide you with a cooling pack for the treatment areas before and after the injections to minimize any pain or bruising. We also offer Pro-Nox, a patient-controlled pain management system that allows you to administer your own pain relief during your treatment. Learn more about Pro-Nox here»
Recovery Time
Daxxify® requires minimal downtime. You can return to your daily activities right away, just avoid strenuous exercise or lying down for four hours after treatment. The injection site sometimes swells and turns red, but these are minor side effects that typically go away after a few hours.
Listen to our podcast where Dr. Gallus and Bri swap stories about their experiences with injectables, including Botox and fillers. Learn what really matters when it comes to getting injectables: skilled injectors, quality products, and timing that keeps you looking smooth, not stiff.
- Key Benefits
- Glossary
- Reduces appearance of wrinkles by temporarily paralyzing the underlying muscles
- Prevents the formation of new wrinkles by restricting the muscle movements that contribute to wrinkle development
- Offers a non-invasive alternative to surgical procedures for facial rejuvenation
- Quick treatment session with no downtime
- Botulinum Toxin Type A: The active ingredient in Daxxify, a neurotoxin used to temporarily relax facial muscles, reducing the appearance of wrinkles.
- Duration of Effects: Refers to how long the aesthetic improvements last after treatment; Daxxify is noted for its longer-lasting results, typically around 6 months or more.
- Dynamic Wrinkles: Wrinkles that form from repetitive facial movements like frowning, smiling, or squinting, which Daxxify can effectively minimize.
- FDA Approval: The U.S. Food and Drug Administration’s endorsement of Daxxify for cosmetic use, indicating it has met safety and efficacy standards.
- Injection Sites: Specific areas on the face where Daxxify is injected to achieve desired results, commonly including the forehead, around the eyes, and between the brows.
- Neuromodulator: A type of drug that affects how nerves and muscles communicate, with Daxxify being one such treatment used in cosmetic procedures to reduce wrinkles.
- Non-Surgical: Procedures that do not involve surgical incisions or removal of tissue.
- Peptide Stabilization: A unique feature of Daxxify, referring to its formulation without human or animal-based components, offering enhanced stability and duration.
- Preventive Treatment: Using Daxxify injections to prevent the formation of wrinkles by relaxing facial muscles before deep lines become established.
- Recovery Time: The minimal downtime required after receiving Daxxify injections, allowing patients to return to daily activities almost immediately.
- Static Wrinkles: Wrinkles visible even when the face is at rest, typically treated with fillers or other skin resurfacing methods rather than neuromodulators like Daxxify.
- Units: The measurement of Daxxify dosage, which varies based on the treatment area, patient goals, and individual muscle strength.
When will I see the results?
You may start to see smoother skin as soon as the day after treatment, and typically within two days. Daxxify® lasts on average six months and up to nine months for some.
With over 20 years of experience, Dr. Gallus is a board certified plastic surgeon and Castle Connolly Top Doctor. She will partner with you to develop a tailored surgical plan that prioritizes your safety and results.
“I have been going to Dr. Gallus since 2019 for treatments including Botox, fillers, IPL, and microneedling with radio frequency. My results since switching to Dr. Gallus have been better than my previous aesthetic doctor. I look much more natural and have very little, if any bruising after injectables. Also, I love the office staff! It’s a very down to earth, relaxed and fun atmosphere.”
—Actual patient of Dr. Gallus
To learn more about your injectable facial rejuvenation options, schedule your consultation with board certified plastic surgeon Dr. Katerina Gallus at Restore SD Plastic Surgery in San Diego.
Dr. Gallus will work with you to understand your goals and achieve them safely with effective and proven treatments and procedures. Call 858-224-2281 or contact us online to schedule an appointment today!
References »
Solish N, Carruthers J, Kaufman J, Rubio RG, Gross TM, Gallagher CJ. Overview of DaxibotulinumtoxinA for Injection: A Novel Formulation of Botulinum Toxin Type A. Drugs. 2021 Dec;81(18):2091-2101. doi: 10.1007/s40265-021-01631-w. Epub 2021 Nov 17. PMID: 34787840; PMCID: PMC8648634.
Carruthers JD, Fagien S, et al. DaxibotulinumtoxinA for Injection for the treatment of glabellar lines: results from each of two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Plastic and Reconstructive Surgery . 2020;145(1):45-58.
Bertucci V, Solish N, Kaufman-Janette J, Yoelin S, Shamban A, Schlessinger J, Snyder D, Gallagher C, Liu Y, Shears G, Rubio RG. DaxibotulinumtoxinA for Injection has a prolonged duration of response in the treatment of glabellar lines: Pooled data from two multicenter, randomized, double-blind, placebo-controlled, phase 3 studies (SAKURA 1 and SAKURA 2). Journal of the American Academy of Dermatology. 2020 Apr;82(4):838-845. doi: 10.1016/j.jaad.2019.06.1313.
Fabi SG, Cohen JL, Green LJ, Dhawan S, Kontis TC, Baumann L, Gross TM, Gallagher CJ, Brown J, Rubio RG. DaxibotulinumtoxinA for Injection for the Treatment of Glabellar Lines: Efficacy Results From SAKURA 3, a Large, Open-Label, Phase 3 Safety Study. Dermatologic Surgery. 2021 Jan 1;47(1):48-54. doi: 10.1097/DSS.0000000000002531.
Green JB, Mariwalla K, Coleman K, et al. A large, open-label, phase 3 safety study of daxibotulinumtoxinA for injection in glabellar lines: a focus on safety from the SAKURA 3 study. Dermatologic Surgery. 2020. doi:10.1097/DSS.0000000000002463
Medically reviewed by Dr. Katerina Gallus — Updated on Jan 13, 2026
